国际先进的乳化分散（凝胶）系统，溶解锅底部出料阀处会出现长晶、乳化时升温速度过长、底部进料时产生物料冲顶现象。生产过程中就要人工开锅，采用手动方式括料，会出现存在残留清不完全、含量不匀、人为微生物带入，数据完整性ALCOA就难以体现正确,都会影响到产品的质量一致性（晶形、结构、含量）。配置国际先进系统，制造出来的产品也不一定是国际一流的。
传统的投粉料方式：锅口进行投入，会在锅壁、搅拌轴等处产生挂粉现象，这部分的粉就不会参与反应或不定期下来，影响到产品质量的一致性（晶形、结构、含量）。
国际化底部投料技术 ：底部真空进料，物料直接与锅内液体接触，搅拌溶入，不会出现上锅口投料产生的粉尘飞扬，影响到产品含量质量。
研究底部投料技术对质量一致性 很有必要，结合工业自动化技术，单靠人工控制（数据无法重复）是达不到国际化、实现自动操作是大势所趋：锅内液体不会从底部漏出、粉料又不会冲出液面到锅顶。达到自动控制进料速度，粉料从底部进来，刚好能溶入液体，不能冲锅顶及真空管道等。液体的粘度、比重、温度、搅拌等参数都有关链，通过寻找合适的方案，有的工艺要求进料速度要快又不冲料的高技术。
实现后成果可广泛应用到高端的API、制剂进粉料，提高制造药物质量一致性的产品质量与生产能力。
达到自动控制进料速度，粉料从底部进来，刚好能溶入液体，不能冲锅顶及真空管道的技术实现，PDCA是少不了的，达到国际先进的乳化分散（凝胶）技术也不一件简单的事。
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